The Enigmatic Brush of Agnolo Di Domenico, Called Del Mazziere Agnolo Di Domenico, known to art history as Agnolo Del Mazziere – or sometimes simply “Master of Santo Spirito” due to the concentration of his work within that Florentine church – remains a fascinatingly elusive figure in the early Renaissance. Born sometime in the first half of the 15th century, likely in Florence itself, his life is shrouded in ambiguity, documented more through his paintings than through biographical accounts. Unlike many of his contemporaries who benefited from extensive patronage records and workshop chroni…