The Enigmatic Brush of Agnolo Di Domenico, Called Del Mazziere Agnolo Di Domenico, known to art history as Agnolo Del Mazziere – or sometimes simply “Master of Santo Spirito” due to the concentration of his work within that Florentine church – remains a fascinatingly elusive figure in the early Renaissance. Born sometime in the first half of the 15th century, likely in Florence itself, his life is shrouded in ambiguity, documented mor…